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Synthesis of novel sugar or azasugar modified anthra[1,2-d] imidazole-6,11-dione derivatives and biological evaluation.
Carbohydrate Research 2018 May 3
A series of novel, sugar or azasugar modified anthra[1,2-d] imidazole-6,11-dione derivatives, with different side chain were synthesized, using the synthetic route of imidazole cyclization reaction of 1,2-diaminoanthraquinone with various sugar (azasugar)-derived aldehydes, and imidazole cyclization reaction of 1,2-diaminoanthraquinone with chloroacetic acid and then followed by the nucleophilic substitution of N-alkylamino azasugar. Their biological activities against HIV-RT and cytotoxic activities against A549, Hela and MCF-7 cells were preliminary evaluated, most compounds showed similar HIV-RT inhibition to the control drug (AZT).
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