The CDKN2A polymorphisms and the susceptibility of HBV-related gestational diabetes mellitus.

BACKGROUND: Single-nucleotide polymorphisms (SNPs) were discovered in HBV-related gestational diabetes mellitus, but it still unclear whether these SNPs are associated with the susceptibility of HBV-related gestational diabetes mellitus.

METHODS: The investigation of the association between CDKN2A polymorphisms and occurrence of HBV-related gestational diabetes mellitus (GDM) in Chinese was assessed in the case-control study. A total of 480 pregnant patients with HBV and 530 pregnant controls were consecutively recruited from January 2015 to December 2016. Polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) method was applied to measure genotyping for the detection of CDKN2A.

RESULTS: The significant differences in the frequency of CDKN2A genotype distributions, rs10811661 and rs564398, were found by Chi-square test. Using conditional logistic analysis, individuals carrying the CDKN2A rs10811661 TC and TT genotypes and CDKN2A rs564398 AA and AG genotypes were related to a greater risk of HBV-related GDM compared with the genotype.

CONCLUSIONS: In conclusion, the CDKN2A rs10811661 and rs564398 polymorphisms showed association with a greater risk of HBV-related GDM in a Chinese population.