Nonvolatile Chemical Constituents from the Leaves of Ligusticopsis wallichiana (DC.) Pimenov & Kljuykov and Their Free Radical-Scavenging Activity.

Different plant parts of Ligusticopsis wallichiana (family: Apiaceae) are widely used as traditional medicines. Although many volatile constituents are already identified from the leaves of L. wallichiana , there is no detailed report on the nonvolatile constituents. In the present study, we aimed to isolate and identify the major chemical constituents from the leaves. Bhutkesoside A ( 1 ), falcarindiol ( 2 ), ferulic acid ( 3 ), cnidioside A ( 4 ), quercetin 3- O - β -D-glucopyranoside ( 5 ), rutin ( 6 ), 4'- O -methylquercetin 3- O - β -D-glucopyranoside ( 7 ), scopoletin ( 8 ), umbelliferone ( 9 ), eugenol 4- O - β -D-glucopyranoside ( 10 ) and pumilaside A ( 11 ) were isolated from the 70% MeOH extract. The structures of isolated compounds were elucidated on the basis of 1 H- and 13 C-NMR spectroscopic data. Compounds 4-11 are reported for the first time from L. wallichiana . Compounds 5 and 6 showed potent free radical-scavenging activity.