Topical Nystatin Treatment for Candida Infection Following Wound Reconstruction.

INTRODUCTION: Wound infection is an important cause of nonhealing wounds and graft rejection.

OBJECTIVE: A series of 5 patients (4 females, 1 male; median age, 50; age range, 1.5-83 years) with nosocomial Candida infection of burns and chronic wounds that were reconstructed with split-thickness skin grafts is presented.

MATERIALS AND METHODS: This case series was carried out between February 2011 and June 2014. Based on tissue cultures, wounds were treated with 100 000 units/mL of nystatin and 25 mg in 500 cc normal saline of mafenide acetate, which resulted in regression of wound infection symptoms and improvement of skin graft take.

CONCLUSIONS: The authors propose this simple, nontoxic, and economic topical treatment for wounds and skin grafts with positive Candida cultures.