We have located links that may give you full text access.
Prognostic Significance of Platelet-Based Inflammatory Indicators in Patients with Gastric Cancer.
World Journal of Surgery 2018 August
BACKGROUND: Thrombocytosis develops in association with malignant tumors and may reflect the inflammation status in cancer patients. This study retrospectively investigated the prognostic significance of two platelet-based inflammatory indicators, the platelet × C-reactive protein multiplier value (P-CRP), and platelet-lymphocyte ratio (PLR), in gastric cancer patients.
METHODS: The 453 enrolled patients had a histopathological diagnosis of gastric adenocarcinoma and underwent curative surgery.
RESULTS: P-CRP correlated significantly with age, tumor size, depth of invasion, lymph node metastasis, and disease stage. A high PLR correlated significantly with tumor size, depth of invasion, lymph node metastasis, lymphatic involvement, venous involvement, and disease stage. In the ROC analysis, the optimal cutoff value of P-CRP and PLR was 3.689 and 173.3, respectively. Five-year survival rates were 62.9 and 82.1% in patients with P-CRPHigh (≥3.689) and P-CRPLow (<3.698), respectively (P < 0.0001). Five-year survival rates were 66.3 and 81.3% in patients with PLRHigh (≥173.3) and PLRLow (<173.3), respectively (P = 0.0022). The prognosis of the P-CRPHigh /PLRHigh group was significantly worse than that of the P-CRPHigh or PLRHigh and P-CRPLow /PLRLow groups in terms of overall survival (P < 0.0001) and disease-specific survival (P = 0.029). In a multivariate analysis, the combination of P-CRP and PLR was an independent prognostic indicator.
CONCLUSIONS: The combination of P-CRP and PLR may be useful in predicting prognosis in gastric cancer patients.
METHODS: The 453 enrolled patients had a histopathological diagnosis of gastric adenocarcinoma and underwent curative surgery.
RESULTS: P-CRP correlated significantly with age, tumor size, depth of invasion, lymph node metastasis, and disease stage. A high PLR correlated significantly with tumor size, depth of invasion, lymph node metastasis, lymphatic involvement, venous involvement, and disease stage. In the ROC analysis, the optimal cutoff value of P-CRP and PLR was 3.689 and 173.3, respectively. Five-year survival rates were 62.9 and 82.1% in patients with P-CRPHigh (≥3.689) and P-CRPLow (<3.698), respectively (P < 0.0001). Five-year survival rates were 66.3 and 81.3% in patients with PLRHigh (≥173.3) and PLRLow (<173.3), respectively (P = 0.0022). The prognosis of the P-CRPHigh /PLRHigh group was significantly worse than that of the P-CRPHigh or PLRHigh and P-CRPLow /PLRLow groups in terms of overall survival (P < 0.0001) and disease-specific survival (P = 0.029). In a multivariate analysis, the combination of P-CRP and PLR was an independent prognostic indicator.
CONCLUSIONS: The combination of P-CRP and PLR may be useful in predicting prognosis in gastric cancer patients.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app