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The B-type natriuretic peptide is a useful biomarker for the estimation of volume overload in children with hypertension in children on peritoneal dialysis.
Nephrology 2018 Februrary 20
AIM: To evaluate the usefulness of serum B-type natriuretic peptide (BNP) as a biomarker of fluid retention in hypertensive children on peritoneal dialysis (PD).
METHODS: We included hypertensive children on PD. We reviewed the changes (∆) of body weight (BWt), blood pressure (BP) and serum BNP at initial and follow-up periods. We presented data as mean±standard deviation (median, minimum - maximum). Wilcoxon signed-rank test was used to evaluate the changes in BWt, BP, and BNP. We applied linear regression analysis for the correlation between the changes of BNP and BP.
RESULTS: We evaluated 56 hypertensive events in 30 patients. Initial findings were BWt 30.5±22.4 (26.5, 3.0 - 93.5) kg, systolic BP (SBP) 153.3±21.5 (150, 110 - 241) mmHg, diastolic BP (DBP) 100.1±22.3, (99.5, 49 - 181) mmHg, BNP 3579.3±6328.9 (1198.5, 305 - 22028) pg/mL. Follow-up results were BWt 29.1±21.3 (25.0, 3.12 - 86) kg, SBP 116.4±17.8 (117.5, 82 - 150) mmHg, DBP 73.3±14.2 (75.0, 42.0 - 101.0) mmHg, BNP 63.5±49.2 (60.5, 2 - 261) pg/mL. ∆SBP (-23.1±13.8, -22.8, -46.9 - 22.5%, P<0.001), ∆DBP (-24.1±19.2, -24.7, -55.6 - 23.2%, P<0.001) and ∆BNP (-93.5±8.1, -96.7, -99.9 - -61.0%, P<0.001) dropped significantly after reduction of ∆BWt (-4.8±4.7, -4.8, -18.7 - 5.6%, P<0.001). The ∆BNP were significantly correlated with ∆SBP (adjusted R square = 0.221, P<0.001) and ∆DBP ( adjusted R square = 0.203, P < 0.001).
CONCLUSIONS: We should measure BNP in hypertensive patients on PD to evaluate the volume status.
METHODS: We included hypertensive children on PD. We reviewed the changes (∆) of body weight (BWt), blood pressure (BP) and serum BNP at initial and follow-up periods. We presented data as mean±standard deviation (median, minimum - maximum). Wilcoxon signed-rank test was used to evaluate the changes in BWt, BP, and BNP. We applied linear regression analysis for the correlation between the changes of BNP and BP.
RESULTS: We evaluated 56 hypertensive events in 30 patients. Initial findings were BWt 30.5±22.4 (26.5, 3.0 - 93.5) kg, systolic BP (SBP) 153.3±21.5 (150, 110 - 241) mmHg, diastolic BP (DBP) 100.1±22.3, (99.5, 49 - 181) mmHg, BNP 3579.3±6328.9 (1198.5, 305 - 22028) pg/mL. Follow-up results were BWt 29.1±21.3 (25.0, 3.12 - 86) kg, SBP 116.4±17.8 (117.5, 82 - 150) mmHg, DBP 73.3±14.2 (75.0, 42.0 - 101.0) mmHg, BNP 63.5±49.2 (60.5, 2 - 261) pg/mL. ∆SBP (-23.1±13.8, -22.8, -46.9 - 22.5%, P<0.001), ∆DBP (-24.1±19.2, -24.7, -55.6 - 23.2%, P<0.001) and ∆BNP (-93.5±8.1, -96.7, -99.9 - -61.0%, P<0.001) dropped significantly after reduction of ∆BWt (-4.8±4.7, -4.8, -18.7 - 5.6%, P<0.001). The ∆BNP were significantly correlated with ∆SBP (adjusted R square = 0.221, P<0.001) and ∆DBP ( adjusted R square = 0.203, P < 0.001).
CONCLUSIONS: We should measure BNP in hypertensive patients on PD to evaluate the volume status.
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