Mechanisms Underlying Neurotoxicity of Silver Nanoparticles.

The potent antimicrobial properties of nanoparticulate silver (AgNPs) have led to broad interest in using them in a wide range of commercial and medical applications. Although numerous in vivo and in vitro studies have provided evidence of toxic effects, rapid commercialization of AgNP-based nanomaterials has advanced without characterization of their potential environmental and health hazards. There is evidence that AgNPs can be translocated from the blood to the brain, regardless the route of exposure, and accumulate in the brain over time. As the brain is responsible for basic physiological functions and controls all human activities, it is important to assess the hazardous influence of AgNPs released from widely used nanoproducts and possible side effects of AgNP-based therapies. A number of studies have suggested that the size, shape and surface coating, as well as rates of silver ion release and interactions with proteins are the key factors determining the neurotoxicity of AgNPs. AgNPs target endothelial cells forming the blood-brain barrier, neurons and glial cells and leads finally to oxidative stress-related cell death. In this chapter, we review in detail current data on the impact of AgNPs on the central nervous system and discuss the possible mechanisms of their neurotoxic effects.