Value of 18 F-FET PET in adult brainstem glioma.

Abdulrahman Abdullah Albatly, Adnan Taleb Alsamarah, Abdulrahman Alhawas, Patrick Veit-Haibach, Alfred Buck, Paul Stolzmann, Irene A Burger, Spyros S Kollias, Martin W Huellner

Clinical Imaging 2018 September

PURPOSE: To investigate 18 F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG).

MATERIALS AND METHODS: FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUVmax , TBR, and time activity curves of FET-PET were calculated.

RESULTS: Progressive gliomas had higher SUVmax (3.57 ± 1.47 vs. 1.60 ± 0.51; p = 0.003) and TBRmax (3.00 ± 1.12 vs. 1.36 ± 0.33; p = 0.001) than stable gliomas. Kaplan-Meier analysis showed longer PFS of tumors with TBRmax  < 2.0 compared to tumors with TBRmax  > 2.0 (665 ± 32 days versus 220 ± 39 days; p < 0.001).

CONCLUSION: FET-PET uptake might be associated with disease progression in adult BSG.

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