A complex systems approach to cancer prevention.

Cancer incidence continues to be a major health problem possibly because cancer is a complex system comprising many agents that interact in a non-linear manner resulting in many possible outcomes. The degree of complexity of a cancer system could be vast involving multiple endogenous and exogenous agents interacting with the over 10 trillion cells comprising the body. It is hypothesized that the practical management of this complexity may be a key to cancer prevention and possibly treatment. But the management and resolution of such an immensely complex system is difficult and may require a multidisciplinary approach including physics, biology, biochemistry and medical science. Research such as in systems biology involving large data sets may offer resolution in time, but the scale of the task is daunting. In evaluating the hypothesis, this paper proposes a method of resolution of the complex cancer system through a proxy in the form of the vital body system, energy balance, involved in several cancer processes. Although I suggest that the energy balance system is itself complex, it may permit access to factors that may be used in limiting cancer initiation. Meta-analysis related to factors of blood sugar, inflammation, stress and immune response reveal that they could be likely candidates for management. Analysis also reveals certain devices that may give practical effect to these management options. Due to the inherent complexity of a cancer system, multiple devices may need to be applied in a combination. The analysis suggests that the low-risk and low-cost devices metformin, vitamin D and vitamin C, may prove to be suitable for use as a practical cancer prevention strategy. If the presented hypothesis is correct, a practical method for prevention or management of cancer may be possible. A trial to test the hypothesis is proposed.