Cytocompatibility and Osteogenesis of Adipose Tissue-Derived Stem Cells on POSS-PEG Coated Collagen.

Nanostructured POSS-PEG nanoparticles (NPs, 42.4 nm ~) synthesized by formation of the urethane linkage between the monoisocyanate group (O═C═N-) of Polyhedral oligosilsesquioxane (POSS) macromers and the diol end groups (-OH) of polyethylene glycol (PEG) homopolymers as catalyzed by dibutyl tin dilaurate are of great interest for biomedical applications. However, NP materials based on nonorganic compounds can be cytotoxic. In this study, the preparation of PEG-POSS NPs followed the coating collagen assembly, which alleviates this problem. They also showed controlled surface properties in such a manner that hydrophobicity and biocompatibility were both reachable to give rise to improved cell viability. It indicates that the PEG-POSS coated collagen was appropriate for the proliferation of adipose tissue-derived stem cells to osteogenesis.