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Surrogate and Intermediate Endpoints in Randomized Trials: What's the Goal?

Edward L Korn, Boris Freidlin
Clinical Cancer Research 2018 May 16
Establishing trial-level surrogacy of an intermediate endpoint for predicting survival benefit in future trials is extremely challenging because of the extrapolations required, but there are other useful drug development and patient management applications of intermediate endpoints. Clin Cancer Res; 24(10); 2239-40. ©2018 AACR See related article by Mushti et al., p. 2268 .

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