HIPPO Stampede in Nerve Sheath Tumors.

M Laura Feltri, Yannick Poitelon

Cancer Cell 2018 Februrary 13

Current therapies for malignant peripheral nerve sheath tumors (MPNSTs) are ineffective. The study by Wu et al. in this issue of Cancer Cell provides evidence that the HIPPO pathway is overactive in human MPNSTs and that combined modulation of LATS1/2-YAP/TAZ and PDGFR signaling in Schwann cells reduces MPNST growth.

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