We have located links that may give you full text access.
Serum cystatin C is independently associated with aortic arterial stiffness in patients with type 2 diabetes.
BACKGROUND: Higher cystatin C levels are associated with an increased cardiovascular risk. We evaluated the association between serum cystatin C and aortic arterial stiffness in patients with type 2 diabetes mellitus (DM).
METHODS: Fasting blood samples were collected from 170 patients with type 2 DM. Carotid-femoral pulse wave velocity (cfPWV) values > 10 m/s were used to define the high aortic arterial stiffness group.
RESULTS: Sixty-seven patients with DM (39.4%) were defined as the high aortic arterial stiffness group. Patients with DM in the high aortic arterial stiffness group had older age (P = 0.003), higher systolic blood pressure (P < 0.001), diastolic blood pressure (P = 0.045), triglyceride (P = 0.046), blood urea nitrogen (P = 0.038), creatinine (P = 0.006), urine albumin-to-creatinine ratio (P = 0.004), and serum cystatin C (P < 0.001) levels but lower estimated glomerular filtration rate (P < 0.001). Multivariate logistic regression analysis showed that serum cystatin C level (each increase of 0.1 mg/l, odds ratio: 1.369, 95% confidence interval (CI): 1.049-1.787, P = 0.021) was still an independent predictor of aortic arterial stiffness in patients with DM.
CONCLUSION: Serum cystatin C level positively correlated with aortic arterial stiffness among patients with type 2 DM.
METHODS: Fasting blood samples were collected from 170 patients with type 2 DM. Carotid-femoral pulse wave velocity (cfPWV) values > 10 m/s were used to define the high aortic arterial stiffness group.
RESULTS: Sixty-seven patients with DM (39.4%) were defined as the high aortic arterial stiffness group. Patients with DM in the high aortic arterial stiffness group had older age (P = 0.003), higher systolic blood pressure (P < 0.001), diastolic blood pressure (P = 0.045), triglyceride (P = 0.046), blood urea nitrogen (P = 0.038), creatinine (P = 0.006), urine albumin-to-creatinine ratio (P = 0.004), and serum cystatin C (P < 0.001) levels but lower estimated glomerular filtration rate (P < 0.001). Multivariate logistic regression analysis showed that serum cystatin C level (each increase of 0.1 mg/l, odds ratio: 1.369, 95% confidence interval (CI): 1.049-1.787, P = 0.021) was still an independent predictor of aortic arterial stiffness in patients with DM.
CONCLUSION: Serum cystatin C level positively correlated with aortic arterial stiffness among patients with type 2 DM.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app