We have located links that may give you full text access.
Posterior Ciliary Artery Occlusion.
Ophthalmology Retina 2018 Februrary
Objective: To compare the severity of ischemic damage following posterior ciliary artery (PCA) occlusion in old, atherosclerotic, hypertensive monkeys to that in young monkeys.
Design: Experimental study.
Subjects: Seven eyes of normal, healthy rhesus monkeys and 8 of old, atherosclerotic, hypertensive monkeys.
Methods: By lateral orbitotomy, all PCAs were cut behind the eyeball in both groups of animals. The fundus and the optic disc were evaluated by repeated ophthalmoscopy, color fundus photography and fluorescein fundus angiography, before and immediately after cutting the PCAs and serially thereafter during the follow-up period.
Main Outcome Measures: Severity of acute ischemic damage to the choroidal, outer retinal and optic nerve head.
Results: Cutting all the PCAs resulted in the development of ischemic infarction of the choroid, retinal pigment epithelium, outer part of the retina and the optic nerve head within 24-hours, in both groups of animals. The severity of the various ischemic fundus and retinal lesions and of the optic disc during the acute phase showed no statistically significant differences between the two groups of animals. Fluorescein fundus angiography soon after cutting the PCAs showed no filling of the entire choroid and the optic disc in both groups of animals. On follow-up for up to about 3 months, in both groups, the white opacity of the infract in the fundus seen during the acute phase gradually resolved in about 2-3 weeks, leaving greyish, granular, depigmented fundus, unmasking of the large choroidal vessels and optic atrophy; fluorescein angiography revealed gradual restoration of the choroidal blood flow and unmasking of the big choroidal vessels.
Conclusions: The study showed that the severity of ischemic damage following occlusion of all the PCAs was similar in both the young healthy and the old, atherosclerotic, hypertensive monkeys. This is in contrast to the findings of our similar study dealing with central retinal artery occlusion, where the young suffered much severe ischemic damage than the old.
Design: Experimental study.
Subjects: Seven eyes of normal, healthy rhesus monkeys and 8 of old, atherosclerotic, hypertensive monkeys.
Methods: By lateral orbitotomy, all PCAs were cut behind the eyeball in both groups of animals. The fundus and the optic disc were evaluated by repeated ophthalmoscopy, color fundus photography and fluorescein fundus angiography, before and immediately after cutting the PCAs and serially thereafter during the follow-up period.
Main Outcome Measures: Severity of acute ischemic damage to the choroidal, outer retinal and optic nerve head.
Results: Cutting all the PCAs resulted in the development of ischemic infarction of the choroid, retinal pigment epithelium, outer part of the retina and the optic nerve head within 24-hours, in both groups of animals. The severity of the various ischemic fundus and retinal lesions and of the optic disc during the acute phase showed no statistically significant differences between the two groups of animals. Fluorescein fundus angiography soon after cutting the PCAs showed no filling of the entire choroid and the optic disc in both groups of animals. On follow-up for up to about 3 months, in both groups, the white opacity of the infract in the fundus seen during the acute phase gradually resolved in about 2-3 weeks, leaving greyish, granular, depigmented fundus, unmasking of the large choroidal vessels and optic atrophy; fluorescein angiography revealed gradual restoration of the choroidal blood flow and unmasking of the big choroidal vessels.
Conclusions: The study showed that the severity of ischemic damage following occlusion of all the PCAs was similar in both the young healthy and the old, atherosclerotic, hypertensive monkeys. This is in contrast to the findings of our similar study dealing with central retinal artery occlusion, where the young suffered much severe ischemic damage than the old.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app