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Journal Article
Review
[Role of mitochondrial dysfunction in the pathogenesis of septic cardiomyopathy].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Februrary
OBJECTIVE: The incidence and mortality of septic cardiomyopathy were high, which is the common cause of death in the patients with sepsis. The pathogenesis of sepsis induced myocardial injury is still unclear. The mitochondrial dysfunction of myocardial cells plays a very important role in the pathophysiological mechanism. This review attempts to introduce the mitochondrial damage of cardiomyocyte from the regulation of mitochondrial energy metabolism, the mechanism of mitochondrial damage, the role of aquaporin and the adjustment of mitochondrial dynamic, in order to provide help for the early prevention of septic cardiomyopathy.
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