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Treatment Response Evaluation using Yttrium-90 in Patients with Rheumatoid Arthritis of Knee Joint.

For radiosynovectomy, we have measured the retention time of yttrium-90 (90 Y) hydroxyapatite (particle size 1-10 μm) within the knee joint space and evaluated the treatment responses in knees with rheumatoid arthritis. Radioactive measurements in the region of knee after injection of 90 Y hydroxyapatite into the joint space were made with a single prove system designed to monitor radioactivity and showed retention of 90 Y in the knee ranged 76.6% ±5.4% after 4 days of injection. The clinical improvements in rheumatoid arthritis of knee joint with steinbroker Stages I and II were increased as time goes by, the improvement ratio is in 72% at 6th months and 76% at 12th months after injection of 90 Y 185 MBq (5 mCi) per joint.

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