N-3 polyunsaturated fatty acids for prevention of postoperative atrial fibrillation: updated meta-analysis and systematic review.

BACKGROUND OR PURPOSE: N-3 polyunsaturated fatty acids (PUFA) have been postulated to have an anti-arrhythmic effect on postoperative atrial fibrillation (POAF), with conflicting results among studies. This study on pooled data evaluated the effect of PUFA on POAF among patients undergoing cardiac surgery.

METHODS: The Pubmed, EMBASE, and CENTRAL databases were searched without restriction on language for randomized controlled trials on the effect of PUFA on POAF that were published before August 31, 2017. The incidence of POAF was extracted as primary endpoint. Pooled data were assessed by using a random-effects model.

RESULTS: Out of 269 articles identified, 14 studies with 3570 patients were eligible and included in the meta-analysis. PUFA reduced incidence of POAF (RR 0.84 [95% CI 0.73-0.98], P = 0.03). The funnel plot and fail-safe number suggested insignificant publication bias. In sensitivity and subgroup analyses, (1) PUFA was effective in preventing POAF for eicosapentaenoic acid (EPA)/DHA < 1 (0.51 [0.36-0.73], P = 0.0003) but not EPA/DHA > 1 or unknown; (2) the efficacy in reducing POAF was apparent when placebo was usual care (0.59 [0.44-0.80], P = 0.0005), but not when placebo was non-fish oils; and (3) PUFA reduced POAF after CABG (0.68 [0.47-0.97], P = 0.03), but not other cardiac surgery.

CONCLUSIONS: PUFA appears to reduce the incidence of POAF. However, the said protective effect may be influenced by EPA/DHA ratio, with < 1 appearing preferable. PUFA efficacy on POAF prevention appeared insignificant when compared with non-fish oils and only apparent in the setting of CABG alone. Further studies are needed to confirm the effect of PUFA on POAF and to assess the proper use of PUFA against POAF.