Relative wave energy-based adaptive neuro-fuzzy inference system for estimation of the depth of anaesthesia.

The advancement in medical research and intelligent modeling techniques has lead to the developments in anaesthesia management. The present study is targeted to estimate the depth of anaesthesia using cognitive signal processing and intelligent modeling techniques. The neurophysiological signal that reflects cognitive state of anaesthetic drugs is the electroencephalogram signal. The information available on electroencephalogram signals during anaesthesia are drawn by extracting relative wave energy features from the anaesthetic electroencephalogram signals. Discrete wavelet transform is used to decomposes the electroencephalogram signals into four levels and then relative wave energy is computed from approximate and detail coefficients of sub-band signals. Relative wave energy is extracted to find out the degree of importance of different electroencephalogram frequency bands associated with different anaesthetic phases awake, induction, maintenance and recovery. The Kruskal-Wallis statistical test is applied on the relative wave energy features to check the discriminating capability of relative wave energy features as awake, light anaesthesia, moderate anaesthesia and deep anaesthesia. A novel depth of anaesthesia index is generated by implementing a Adaptive neuro-fuzzy inference system based fuzzy c-means clustering algorithm which uses relative wave energy features as inputs. Finally, the generated depth of anaesthesia index is compared with a commercially available depth of anaesthesia monitor Bispectral index.