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The Family of LPS Signal Transducers Increases: the Arrival of Chanzymes.

Francesca Granucci
Immunity 2018 January 17
After LPS recognition, the MyD88-dependent and the TRIF-dependent pathways are consecutively activated in macrophages. Schappe et al. (2018) show that the chanzyme TRPM7 is required for an efficient LPS receptor complex endosomal relocation and the activation of the TRIF pathway.

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