HIV Immunogens: Affinity Is Key.

Savit Prabhu, Ian A Cockburn, Carola G Vinuesa

Immunity 2018 January 17

Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers.

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