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Journal Article
Review
Controlling Selectivity in Aliphatic C-H Oxidation through Supramolecular Recognition.
Chemistry : a European Journal 2018 April 7
Aliphatic C-H oxidation is the most straightforward approach to functionalize hydrocarbon skeletons. The main challenge of this reaction is the control of site selectivity, given the multiple C-H bonds present in any organic molecule. Natural enzymes elegantly solve this problem through the interplay of different interactions that geometrically orient the substrate to expose a single C-H bond to the active unit, thus overriding intrinsic reactivity patterns. A combination of molecular catalysts and supramolecular receptors can be a promising way to replicate such control. This strategy indeed unlocks hydroxylation of C-H bonds that are not accessible with conventional methodologies, in which the selectivity is dictated by the geometry of the substrate-receptor adduct. Herein, we review the reports of recognition-driven C-H oxidation reactions and highlight the key design principles that inspired these works.
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