Multifactorial Splenomegaly.

Splenomegaly is an unusual finding among North Americans, but is commonly seen in many parts of the world. Increasingly, it can be encountered locally among recent immigrant and refugee populations. A broad differential diagnosis is required. We report the case of a 33-year-old refugee with multiple potential causes for splenomegaly. Empiric treatment of one of the infectious contributors to his splenomegaly resulted in a significant improvement of his quality of life, illustrating the importance of a thorough evaluation of potential causes of splenomegaly, especially in refugee and immigrant populations.