We have located links that may give you full text access.
Extending the Scope of 19 F Hyperpolarization through Signal Amplification by Reversible Exchange in MRI and NMR Spectroscopy.
ChemistryOpen 2018 January
Fluorinated ligands have a variety of uses in chemistry and industry, but it is their medical applications as 18 F-labelled positron emission tomography (PET) tracers where they are most visible. In this work, we illustrate the potential of using 19 F-containing ligands as future magnetic resonance imaging (MRI) contrast agents and as probes in magnetic resonance spectroscopy studies by significantly increasing their magnetic resonance detectability through the signal amplification by reversible exchange (SABRE) hyperpolarization method. We achieve 19 F SABRE polarization in a wide range of molecules, including those essential to medication, and analyze how their steric bulk, the substrate loading, polarization transfer field, pH, and rate of ligand exchange impact the efficiency of SABRE. We conclude by presenting 19 F MRI results in phantoms, which demonstrate that many of these agents show great promise as future 19 F MRI contrast agents for diagnostic investigations.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app