We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Intercellular transfer of mitochondria rescues virus-induced cell death but facilitates cell-to-cell spreading of porcine reproductive and respiratory syndrome virus.
Virology 2018 April
Our recent study showed that intercellular tunneling nanotubes (TNTs) serve as an alternative pathway for cell-to-cell spreading of infectious materials of porcine reproductive and respiratory syndrome virus (PRRSV). In this study, we found that PRRSV infection could induce the formation of TNTs between infected and uninfected cells. Co-culturing PRRSV-infected cells with uninfected cells, including porcine umbilical cord stem cells, rescued PRRSV-induced cell death. Mitochondrion, an important regulator of cell survival/death, was observed transferring from uninfected to PRRSV-infected cells. Importantly, impaired formation of nanotube or defective mitochondrion was unable to rescue infected cells from apoptosis/necrosis. Certain PRRSV proteins were detected to associate with mitochondria and transport from infected to uninfected cells through TNTs. Our results suggest that TNTs-transfer of functional mitochondria rescued PRRSV-infected cells from apoptosis/necrosis in the early stage of infection. On the other hand, mitochondria could be utilized as a vehicle to transport viral materials for spreading the infection.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app