Add like
Add dislike
Add to saved papers

Comparative study of porcine anti-human lymphocyte immunoglobulin and rabbit anti-human thymocyte immunoglobulin as a first-line treatment of acquired severe aplastic anemia.

Leukemia Research 2018 Februrary
Porcine anti-human lymphocyte immunoglobulin (pALG) and rabbit anti-human thymocyte immunoglobulin (rATG) are the only two ATGs for severe aplastic anemia (SAA) treatment in China. 148 treatment-naïve SAA patients who received ATG combined with cyclosporine A (CsA) therapy were analysed retrospectively. The patients were divided into a pALG group (n = 114) and a rATG group (n = 34). After three months, the pALG and rATG groups had an overall response (OR) of 65.8% and 44.1%, respectively (P = 0.023); after six months, the OR reached 74.6% and 64.7%, respectively (P = 0.361). The pALG group had markedly better time-related efficacy than the rATG group (P = 0.03). The overall survival (OS) and event-free survival (EFS) between groups had no significant difference (P > 0.1). The pALG and rATG groups did not significantly differ in terms of recurrence (8.8% vs. 5.9%, P = 0.734) or PNH clonal transformation (5.3% vs. 2.9%, P = 1.000), whereas a significant difference was found in the incidence of MDS/AML transformation (2.6% vs. 11.8%, P = 0.049). We found that pALG achieved a better time-related efficacy than rATG for the treatment of SAA; nonetheless, no significant difference in the OS or EFS of pALG compared with rATG.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app