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Turning up the Heat with Therapeutic Epigenome Editing.

Alexandra Zezulin, Kiran Musunuru
Cell Stem Cell 2018 January 5
CRISPR-Cas9 has been touted for therapeutic genome editing, but limitations include inefficient correction of disease-causing mutations and off-target mutagenesis. In the latest issue of Cell, Liao et al. (2017) show that a modified version of CRISPR-Cas9 can target and activate key therapeutic genes in vivo without altering DNA sequence identity.

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