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Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
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Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward.

Krishna C Vadodaria, Debha N Amatya, Maria C Marchetto, Fred H Gage
Genome Medicine 2018 January 5
Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges.

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