We have located links that may give you full text access.
Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat.
Iranian Journal of Basic Medical Sciences 2017 November
Objectives: Oxidative stress has a pivotal role in the pathogenesis of diabetic retinopathy (DR). Juglans regia L . (JRL) leaf extract has hypoglycemic and antioxidative properties. This study aimed to determine the ameliorative effects of JRL against diabetic retinopathy.
Materials and Methods: The DR rat model was generated by injection of streptozotocin (STZ). A subset of the diabetic rats received JRL or metformin after the onset of hyperglycemia. Histopathology and immunohistochemistry of apoptotic and inflammatory factors were assessed along with biochemical assessments of lipid peroxidation and antioxidant status.
Results: Lipid peroxidation level and catalase activity significantly improved after JRL consumption ( P <0. 001). Degeneration of the retina attenuated after JRL consumption. Attenuation of the caspase-3, COX-2, PARP, and S100B expression could be detected significantly ( P <0. 001) in the JRL-treated rats. While, blood glucose level decreased after JRL consumption ( P <0. 001).
Conclusion: JRL leaf extract exert protective effects against diabetic retinopathy.
Materials and Methods: The DR rat model was generated by injection of streptozotocin (STZ). A subset of the diabetic rats received JRL or metformin after the onset of hyperglycemia. Histopathology and immunohistochemistry of apoptotic and inflammatory factors were assessed along with biochemical assessments of lipid peroxidation and antioxidant status.
Results: Lipid peroxidation level and catalase activity significantly improved after JRL consumption ( P <0. 001). Degeneration of the retina attenuated after JRL consumption. Attenuation of the caspase-3, COX-2, PARP, and S100B expression could be detected significantly ( P <0. 001) in the JRL-treated rats. While, blood glucose level decreased after JRL consumption ( P <0. 001).
Conclusion: JRL leaf extract exert protective effects against diabetic retinopathy.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app