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Case Reports
Journal Article
A case of IgG 4 oligoarthritis mimicking psoriatic arthritis.
BMJ Case Reports 2018 January 4
IgG4 -related disease (IgG4 -RD) is a rare but rapidly emerging immune-mediated fibroinflammatory condition that can affect almost any organ. It is typically associated with involvement of organs such as lymph nodes, submandibular glands, orbits, periaortic region and pancreas. However, IgG4 -RD presenting primarily as an inflammatory arthritis is much less recognised. We present a rare case of IgG4 -RD mimicking psoriatic arthritis. In spite of normal circulating IgG4 plasma levels, a clinical index of suspicion was required to obtain a histopathological diagnosis. The patient's aggressive arthritis disease did not initially respond to typical disease- modifying agents such as methotrexate. Instead, we report a dramatic response to B cell depletion with rituximab. It is important to emphasise this case as a rare presentation of a rare disease. IgG4 -RD is a rapidly emerging condition and the diagnosis should be considered when the alternatives do not seem to fit.
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