Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review.

In worldwide lung cancer shares 14% among the newly diagnosed cancer cases. Currently, the numbers of drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect. Coumarin scaffold became an attractive subject due to their broad spectrum of pharmacological activities. Coumarin derivatives extensively explored for anticancer activities as it possesses minimum side effect along with multi-drug reversal activity. Coumarin is a potent inhibitor of variety of proteins including EGFR, tyrosine kinase, ERK1/2, PI3K, HSP 90, Bax, STAT proteins, NF-κB and tTelomerase whicUpon analyzing the structure activity relationship, it was found that N-aryl carboxamide, phenyl substitution at C-3 position and 1,2,3- triazolyl, trihydroxystilbene, amino substitution at C-4 position of the coumarin nucleus was most effective in targeting lung cancer. h have been associated with lung cancer. This review is a collaborative and extensive compilation of synthetic strategies, mechanism of action, and structure activity relationship thereof for the management of lung carcinoma.