We have located links that may give you full text access.
Case Reports
Journal Article
Histiocytic Sarcoma with p16-Overexpression Presenting as Uterine Cervical Mass.
Annals of Clinical and Laboratory Science 2017 November
A 67-year-old woman presented with post-menopausal bleeding. Physical examination and imaging revealed a cervical mass with extensive pelvic involvement and supraclavicular lymphadenopathy. Clinical diagnosis was stage IVB cervical carcinoma. Cervical biopsy revealed high-grade squamous intraepithelial lesion and epithelioid tumor cells in the stroma. Lymph node biopsy revealed metastasis by similar epithelioid tumor cells. The epithelioid tumor cells were positive for p16, CD68, and CD163 on immunohistochemical study. The diagnosis of histiocytic sarcoma (HS) was rendered. This case demonstrated a rare presentation of HS mimicking cervical carcinoma. Awareness of this rare entity with appropriate ancillary tests is essential for accurate diagnosis. In contrast to the previous postulation of p16-inactivation as the pathogenesis of HS, p16-overexpression might suggest a different pathway for tumorigenesis.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app