Investigation of antitumor effects of Lactobacillus crispatus in experimental model of breast cancer in BALB/c mice.

Elahe Motevaseli, Mohammad Reza Khorramizadeh, Jamshid Hadjati, Samad Farashi Bonab, Solat Eslami, Soudeh Ghafouri-Fard

Immunotherapy 2018 Februrary

AIM: To evaluate the effect of intraperitoneal injections of heat-killed Lactobacillus crispatus on breast tumor size and overall survival of Balb/c mouse received 4T1 mammary carcinoma. Materials and methods: Different doses of L. crispatus have been injected intraperitoneally in BALB/c mice.

RESULTS: Tumor size was decreased in the experiment group treated with 1 × 108 bacteria/200 μl. Treatment with 1 × 108 bacteria/200 μl resulted in survival improvement. The myeloid-derived suppressor cells and reactive oxygen species production have been increased in all groups. Cox2 expression decreased in tumor tissues of the mice treated with 108 bacteria/200 μl. The expressions of Arginase and iNos increased in the spleen and tumor tissues of those treated with 5 × 108 bacteria/200 μl.

CONCLUSION: We have shown the protective effect of L. crispatus on survival of tumor-bearing mice.

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