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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Is It Our Duty To Hunt for Pathogenic Mutations?
Trends in Molecular Medicine 2018 January
Should professionals systematically screen whole-genome sequencing (WGS) data to check for life-threatening mutations? Alternatively, should genome analysis focus on the primary reason for testing - that is, aiming to achieve precision medicine? We present an ethical review of the arguments and compare the act of searching for mutations with disclosing mutations that are discovered incidentally.
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