A cross-sectional study on the use and misuse of trypanocides in selected pastoral and agropastoral areas of eastern and northeastern Tanzania.

BACKGROUND: Tsetse-borne African animal trypanosomosis (AAT) greatly influences livestock distribution and significantly slows livestock productivity in sub-Saharan Africa. While a number of control methods targeting the vector tsetse are in field application, treatment with the few available trypanocides continues to be the most widely applied control method. Unfortunately, improper and frequent use of these few available drugs, accelerated by poor veterinary service delivery, promotes trypanosome drug resistance, the magnitude of which has not been delineated. In the present study, current practices on trypanocide application for the control of bovine trypanosomosis in the field in Tanzania were studied with a view to providing policy advice on the safe and sustainable use of trypanocides.

METHODS: A cross-sectional study was conducted using a semi-structured questionnaire administered to a total of 200 randomly selected livestock keepers in selected pastoral and agropastoral areas within three districts in eastern and north eastern Tanzania.

RESULTS: In total, 50% of respondents in all three study districts had primary level education; over 40% had informal education and only 5% with university education (all from one district, Pangani). Age-wise, most respondents were aged 30-59 years with exception of Korogwe where 35% were aged 20-29 years. Over 95% of respondents had knowledge on tsetse as a vector of trypanosomosis and correctly identified tsetse in provided pictures. Furthermore, 98.7% of the respondents applied pyrethroids for vector control. Regarding parasite control practices, this study revealed a high degree of variation in trypanocides usage and the intervals of their application. Whereas only 20% of respondents use chemoprophylaxis for trypanosomosis control, the majority (69-95%) wrongly use diminazene aceturate thinking it is prophylactic, while only 5-30% used the prophylactic drug isometamidium chloride. Most of the respondents (95% in Korogwe, 60% in Pangani and 93.1% in Mvomero) administered the drugs on their own. Improper trypanocides administration was high as respondents in Korogwe (75%) and Mvomero (72%) administered the drugs intravenously with a view to achieving faster drug effect contrary to manufacturers' recommendations, while 40% of respondents from Pangani used both intravenous and intramuscular routes. Additionally, respondents did not observe the recommended withdrawal periods for the drugs.

CONCLUSIONS: This study revealed a high level of trypanocides misuse which poses a high risk of trypanosome drug resistance development as well as risks to human health from drug residues in consumed animal products. This calls for improvements in veterinary service delivery in pastoral and agropastoral areas of Tanzania to counteract the misuse of chemotherapeutics.