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Journal Article
Research Support, Non-U.S. Gov't
An Animal Model of Alzheimer Disease Based on the Intrahippocampal Injection of Amyloid β-Peptide (1-42).
The intrahippocampal injection of amyloid beta peptide (1-42) (Aβ(1-42) ) represents one of the most useful animal models of Alzheimer disease. Since none of these available models fully represents the main pathological hallmarks of Alzheimer disease, stereotaxic Aβ(1-42) infusion provides researchers with an in vivo alternative paradigm. When performed by well-trained individuals, this model is the best-suited one for short-term studies focusing on the effects of Aβ(1-42) on a specific brain region or circuitry. Here, we describe all methodological phases of such a model.
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