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PSMA brings new flavors to PI3K signaling: A role for glutamate in prostate cancer.
Journal of Experimental Medicine 2018 January 3
In this issue of JEM, Kaittanis et al. (https://doi.org/10.1084/jem.20171052) report a new signaling role for prostate-specific membrane antigen (PSMA), providing a mechanistic link between two major oncogenic pathways, as well as promising therapeutic implications for the diagnosis and treatment of prostate cancer.
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