Xanthones and Quinolones Derivatives Produced by the Deep-Sea-Derived Fungus Penicillium sp. SCSIO Ind16F01.

Chemical investigation of the fungus Penicillium sp. SCSIO Ind16F01 derived from deep-sea sediment sample afforded a new xanthone, 3,8-dihydroxy-2-methyl-9-oxoxanthene-4-carboxylic acid methyl ester ( 1 ) and a new chromone, coniochaetone J ( 2 ), together with three known xanthones, 8-hydroxy-6-methyl-9-oxo-9 H -xanthene-1-carboxylic acid methyl ester ( 3 ), 7,8-dihydroxy-6-methyl-9-oxo-9 H -xanthene-1-carboxylic acid methyl ester ( 4 ), 1,6,8-trihydroxy-3-(hydroxymethyl)anthraquinone ( 5 ), three known chromones, coniochaetone B ( 6 ), citrinolactones B ( 7 ), epiremisporine B ( 8 ), and four reported rare class of N -methyl quinolone lactams: quinolactacins B ( 9 ), C1 ( 10 ), and C2 ( 11 ), and quinolonimide ( 12 ). The structures of new compounds were determined by analysis of the NMR and MS spectroscopic data. Those isolated compounds were evaluated for their antiviral (EV71 and H3N2) and cytotoxic activities.