Add like
Add dislike
Add to saved papers

Task-based metabolic changes in the left dorsolateral prefrontal region during the letter N-back working memory task using proton magnetic resonance spectroscopy.

Neuroreport 2018 January 18
Neuroimaging and electrophysiological studies have consistently provided evidence on the role of dorsolateral prefrontal cortex in working memory. Recent studies have shown that the changes in metabolites in the brain could be detected upon functional activation using proton magnetic resonance spectroscopy. Therefore, we carried out a study in healthy control participants to understand the changes in metabolites during a letter N-back working memory task in the left dorsolateral prefrontal region. Single-voxel spectra were acquired from the left dorsolateral prefrontal region in 10 healthy control participants. The concentrations of metabolites were measured using a point-resolved spectroscopy sequence at three different time points, namely, before, during, and after the performance of the task. Repeated-measures analysis of variance indicated a main effect of time for glutamate concentrations and not for other metabolites. The healthy control participants showed a significant increase in glutamate concentrations during the performance of the letter N-back task. It was then followed by a significant decrease in the glutamate concentrations returning to the baseline after the task. The proposed method would be useful in understanding the dynamic changes in glutamate during the letter N-back task to examine the cognitive impairment in various neurodegenerative and psychiatric disorders.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app