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Sestrin1, a tumor suppressor that can be rescued.

Maria C Donaldson, Natalya Katanayeva, Elisa Oricchio
Molecular & Cellular Oncology 2017
SESTRIN1 is a tumor suppressor in follicular lymphoma that controls mTORC1 activity and it is inactivated by chromosomal deletions or epigenetically silenced by mutant EZH2Y641X . Pharmacological inhibition of EZH2 promotes SESTRIN1 re-expression and it restores its tumor suppressive activity, suggesting the possibility to epigenetically control mTORC1 activity.

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