We have located links that may give you full text access.
Multi-residue analysis of sedative drugs in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 2018 January 2
BACKGROUND: Sedative drugs are often used for the treatment of depression, anxiety and insomnia and they are involved in many forensic cases. This work established a method for the simultaneous determination of multi-groups of sedative drugs (benzodiazepines, barbitals, phenothiazines, tricyclic antidepressant and butyrophenone) in human plasma for forensic analysis. A large number of sedative drugs with forensic interest can be analyzed in a short time with lower limits of quantification by combination of SPE extraction and ultra performance liquid chromatography-tandem mass spectrometry.
METHODS: Sample preparation consisted of extraction of the plasma by hydrochloric acid solution and further purified by SLW solid phase extraction column.
RESULTS: The method was fully validated to cover large concentration ranges of 50-1000μg/L for 5 Barbital drugs, while 1.0-50μg/L for the other 14 sedative drugs. The average recoveries of the drugs spiked at three levels ranged from 65.3% to 114.3% with the relative standard deviation between 1.2% and 13.2%. The lowest limits of quantification (LLOQ) were 100μg/L for Barbital drugs and1.0μg/L for all the other 14 drugs.
CONCLUSIONS: This validated method has been successfully used in emergency analysis of multi-residues of sedative drugs in plasma.
METHODS: Sample preparation consisted of extraction of the plasma by hydrochloric acid solution and further purified by SLW solid phase extraction column.
RESULTS: The method was fully validated to cover large concentration ranges of 50-1000μg/L for 5 Barbital drugs, while 1.0-50μg/L for the other 14 sedative drugs. The average recoveries of the drugs spiked at three levels ranged from 65.3% to 114.3% with the relative standard deviation between 1.2% and 13.2%. The lowest limits of quantification (LLOQ) were 100μg/L for Barbital drugs and1.0μg/L for all the other 14 drugs.
CONCLUSIONS: This validated method has been successfully used in emergency analysis of multi-residues of sedative drugs in plasma.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
Perioperative echocardiographic strain analysis: what anesthesiologists should know.Canadian Journal of Anaesthesia 2024 April 11
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app