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Assorted applications of N-substituted-2,4-thiazolidinediones in various pathological conditions.
Mini Reviews in Medicinal Chemistry 2017 November 30
Thiazolidine-2,4-dione (TZD), one of the most frequently encountered heterocyclic ring which has been implicated in design and synthesis of entities for various pathogenic conditions including cancer. Since its discoveryvarious substitutions at 5th position has been carried out and reviewed. Various substitutions at 5th position has led to generation of glitazones, whose target peroxisome proliferating activated receptor γ (PPARγ) was found decade after their discovery.Acidichydrogen (-NH) of TZD is prime pharmacophoric requirement for activation of PPARγ. However, advanced in silico techniques have helped to design compounds bearing substitutions at both methylene and -NH group of TZD, targeting range of enzymes involved in various pathological conditions viz.,diabetes, hyperlipidemia, infectious disease, inflammation and cancer. The promising activities shown by methylene and N-substituted TZDsin above mentioned therapeutic areas, prompted us to collate the information which would help researchers to alter the structure of existing ligands and to design new TZD derivatives with better safety and efficacy profiles.
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