We have located links that may give you full text access.
Overexpressed miR-128a enhances chemoradiotherapy to laryngeal cancer cells and its correlation with BMI1.
Future Oncology 2018 March
AIM: To clarify the function of miR-128a on radiotherapy and chemotherapy resistance in laryngeal cancer and explore the possible mechanism.
MATERIALS & METHODS: Hep-2 and AMC-HN-8 cell lines were cultured. MiR-128a was upregulated utilizing lentiviral transfection. Through radiotherapy and chemotherapy assays, the function of miR-128a on chemoradiotherapy was evaluated. The correlation of miR-128a with BMI1 was identified by performing real-time PCR.
RESULTS: The hsa-miR128a cell line was established. The chemotherapy assay revealed that an overexpression of miR-128a decreases the inhibition to chemotherapy. The radiotherapy assay showed that miR-128a promotes the radiotherapy sensitivity. The expression of BMI1 decreased with overexpression of miR-128a.
CONCLUSION: miR-128a confers chemoradiotherapy sensitivity of laryngeal cancer cells and targeting BMI1 gene is a possible mechanism of the effect.
MATERIALS & METHODS: Hep-2 and AMC-HN-8 cell lines were cultured. MiR-128a was upregulated utilizing lentiviral transfection. Through radiotherapy and chemotherapy assays, the function of miR-128a on chemoradiotherapy was evaluated. The correlation of miR-128a with BMI1 was identified by performing real-time PCR.
RESULTS: The hsa-miR128a cell line was established. The chemotherapy assay revealed that an overexpression of miR-128a decreases the inhibition to chemotherapy. The radiotherapy assay showed that miR-128a promotes the radiotherapy sensitivity. The expression of BMI1 decreased with overexpression of miR-128a.
CONCLUSION: miR-128a confers chemoradiotherapy sensitivity of laryngeal cancer cells and targeting BMI1 gene is a possible mechanism of the effect.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices 
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app