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Ru/Ni Dual Catalytic Desulfinative Photoredox C sp 2 -C sp 3 Cross-Coupling of Alkyl Sulfinate Salts and Aryl Halides.
Organic Letters 2017 December 16
A mild Ru/Ni dual catalytic desulfinative photoredox Csp2 -Csp3 cross-coupling reaction of alkyl sulfinate salts with aryl halides has been developed. The optimized catalyst system, consisting of Ru(bpy)3 Cl2 , Ni(COD)2 , and DBU, smoothly mediates the coupling of a diverse set of secondary and primary nonactivated alkyl sulfinate salts with a broad range of electron-deficient aryl bromides, electron-rich aryl iodides, and heteroaryl bromides under irradiation with blue light. The procedure is ideal for late-stage introduction of alkyl groups on pharmaceutical intermediates, and the Csp2 -Csp3 cross-coupling reaction allowed the rapid synthesis of caseine kinase 1δ inhibitor analogues via a parallel medicinal chemistry effort.
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