IL-1β gene polymorphism and serum levels in a Tunisian population with acute heart failure.

AIM: The aim of this study was to explore the relationship between IL-1β-31T/C polymorphism and serum levels of IL-1β and the risk of acute heart failure (AHF).

METHODS: A total of 320 dyspnea patients (160 with AHF and 160 without AHF) and 100 healthy subjects were included in this study. IL-1β genotyping was performed by PCR-restriction fragment length polymorphism technique.

RESULTS: Concentration of IL-1β was significantly higher in patients with heart failure (HF) compared with non-HF and control groups. Results of the distribution of IL-1β-31T/C genotypes and allele frequencies did not show any significant difference between the three groups. Serum levels of IL-1β were found to be higher among TT genotype than TC and CC genotype.

CONCLUSION: IL-1β levels may be useful for the evaluation of diagnosis in acutely decompensated HF.