[Monitoring of neurotrophic factors and cognitive function in patients with traumatic brain injury].

AIM: To study the neurological and cognitive status in comparison to the quantitative content of blood serum neurotrophic factors of patients with acute and long-term brain injury during treatment with cerebrolysin.

MATERIAL AND METHODS: Eighty patients, 56 men and 24 women, aged from 18 to 64 years, were examined in acute and long-term periods of the brain injury of moderate severity. An open, comparative, randomized study was performed before and after treatment with cerebrolysin.

RESULTS AND CONCLUSION: Cognitive impairment, dysregulation type in the acute and long-term brain injury of mild to moderate severity was associated with the low content of brain-derived neurotrophic factor. These disorders were clinically more pronounced in patients with the damage of the frontal and temporal lobes. After treatment with cerebrolysin, a significant positive dynamics on the scale of frontal dysfunction and increased levels of serum brain-derived neurotrophic factor were identified.