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Robustness versus evolvability analysis for regulatory feed-forward loops.
Journal of Bioinformatics and Computational Biology 2017 December
From the definition, it appears that phenotypic robustness and evolvability of an organism are inversely related to each other. However, a number of studies exploring this question have found conflicting evidences in this regard. This question motivated the current work where we explore the relationship between robustness and evolvability. As a model system, we pick the Feed Forward Loops (FFLs), and develop a framework to characterize their performance in terms of their ability to resist changes to steady state expression (robustness), and their ability to evolve towards novel phenotypes (evolvability). We demonstrate that robustness and evolvability are positively correlated in some FFL topologies. We compare this against other small regulatory topologies, and show that the same trend does not hold among them. We postulate that the ability to positively link robustness and evolvability could be an additional reason for over-representation of FFLs in living organisms, as compared to other regulatory topologies.
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