A new analytical model for the changes of vascular endothelial growth factor in ischemic diseases.

Vascular endothelial growth factors (VEGFs) play an important role in ischemic diseases. However, few studies focused on the generation and decay process of VEGF and no model yet can quantify different VEGF behavior caused in different area, like heart or brain. We compare the results across different groups and quantify the effectiveness of the selected training protocols. By applying the model to experimental data, the analytical model has been proposed to simulate the changes of vascular endothelial growth factor as a function of time and training protocols in ischemic diseases. The model is also used to study the generation and decay processes of VEGF and bFGF. A good quantitative correlation between the stroke area and parameters used in the model has been discovered.