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Reactions between methylglyoxal and its scavengers in-vivo appear to be catalyzed enzymatically.

Benjamin Szwergold
Medical Hypotheses 2017 November
Methylglyoxal (MGO) is thought to be an important contributor to the development of diabetic complications. In this paper I propose that MGO, not detoxified by the glyoxalase system, is removed from circulation by MGO-scavengers. Furthermore, since intrinsic rates of reactions between MGO and its scavengers are low, I propose that, in-vivo, these reactions are catalyzed enzymatically.

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