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S -Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S -Adenosyl-L-methionine's chemistry, physiology and pharmacokinetics.
World Journal of Gastroenterology : WJG 2017 October 29
S -Adenosyl-L-methionine (SAM) is a cofactor serving as a methyl donor in numerous enzymatic reactions. It has been reported that SAM has the potential to modify antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus -expressing cells at millimolar concentrations. The efficacy of SAM at micromolar concentrations and the underlying mechanisms remain to be demonstrated.
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