[The prognostic significance of plasma Epstein-Barr virus DNA in patients with diffuse large B cell lymphoma].

To retrospectively analyze the prognostic significance of plasma Epstein-Barr virus (EBV) DNA in 122 patients with diffuse large B cell lymphoma (DLBCL). Plasma EBV DNA positivity was related to advanced disease stage ( P =0.030), B symptoms ( P =0.004) and elevated serum lactic dehydrogenase (LDH) ( P =0.001). Furthermore, univariate analysis indicated that plasma EBV DNA level was associated with worse overall survival (OS) ( HR =0.223, 95% CI 0.096-0.518, P <0.001) and worse progression free survival (PFS) ( HR =4.417, 95% CI 1.911-10.208, P <0.001), whereas multivariate analysis showed plasma EBV DNA as a probable independent prognostic factor of clinical outcome( HR =0.409, 95% CI 0.166-1.008, P =0.052).